自身免疫性疾病

合作單位：北京大學(xué)人民醫(yī)院、貴州中醫(yī)藥大學(xué)

研究?jī)?nèi)容：通過(guò)對(duì)類風(fēng)濕性關(guān)節(jié)炎、骨關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡等免疫性疾病的大規(guī)模研究，探索其腸道及口腔微生物組信號(hào)及致病機(jī)理，開發(fā)針對(duì)自身免疫病的微生物干預(yù)方案。

研究成果：

1. Ruochun Guo, ... (2022) Dysbiotic oral and gut viromes in untreated and treated rheumatoid arthritis patients. Microbiology Spectrum.
2. ..., Qiulong Yan, ... (2022) Characterizations of the gut bacteriome, mycobiome, and virome in patients with osteoarthritis. Microbiology Spectrum.
3. ..., Shenghui Li, ... (2022) Tonsillar microbiome-erived lantibiotics induce structural changes of IL-6 and IL-21 receptors and modulate host immunity. Advanced Science.
4. ..., Shenghui Li, ... (2019) Mining the human tonsillar microbiota as autoimmune modulator. bioRxiv.

消化系統(tǒng)疾病

合作單位：大連醫(yī)科大學(xué)、中山大學(xué)附屬腫瘤醫(yī)院

研究?jī)?nèi)容：通過(guò)對(duì)結(jié)直腸癌、炎癥性腸病、腸易激綜合征、膽囊炎等消化系統(tǒng)疾病的研究，挖掘腸道微生物的機(jī)理和診斷價(jià)值，分離特異性的致病菌和有益菌，為臨床預(yù)防和治療提供幫助。

研究成果：

1. Fang Chen, ... (2022) Meta-analysis of fecal viromes demonstrates high diagnostic potential of the gut viral signatures for colorectal cancer and adenoma risk assessment. Journal of Advanced Research.
2. ..., Shenghui Li, ... (2022) Cultivated human intestinal fungus Candida metapsilosis attenuates colitis by secreting acyclic sesquiterpenoids as FXR agonists. Gut.
3. Qiulong Yan, ... (2021) Cultivation and genomic characterization of the bile bacterial species from cholecystitis patients. Frontiers in Microbiology.
4. ..., Qiulong Yan, ... (2015) Acute cholecystitis associated with infection of Enterobacteriaceae from gut microbiota. Clinical Microbiology and Infection.

慢性和老年疾病

合作單位：中國(guó)農(nóng)業(yè)大學(xué)、中國(guó)科學(xué)院生命科學(xué)研究所、廣州醫(yī)科大學(xué)

研究?jī)?nèi)容：通過(guò)對(duì)高血壓、冠心病、慢性腎病、糖尿病、阿茲海默癥等疾病的腸道微生物組和代謝組研究，探索微生物對(duì)人體代謝系統(tǒng)和疾病的作用，為慢性和老年疾病的預(yù)防和干預(yù)提供指導(dǎo)。

研究成果：

1. ..., Shenghui Li, ... (2022) Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression. Molecular Psychiatry.
2. ..., Shenghui Li, ... (2021) Comparison of the gut microbiota of short-term and long-term medical workers and non-medical controls: a cross-sectional analysis. Clinical Microbiology and Infection.
3. ..., Shenghui Li, ... (2021) Characterization of the genitourinary microbiome of 1,165 middle-aged and elderly healthy individuals. Frontiers in Microbiology.
4. ..., Shenghui Li, ... (2020) Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut.
5. ..., Shenghui Li, ... (2020) An A. muciniphila subtype alleviates high-fat diet-induced metabolic disorders and inhibits the neurodegenerative process in mice. Anaerobe.
6. Qiulong Yan, ... (2017) Alterations of the gut microbiome in hypertension. Frontiers in Cellular and Infection Microbiology.
7. Zhuye Jie, ... (2017) The gut microbiome in atherosclerotic cardiovascular disease. Nature Communications.

母嬰微生物組及妊娠期疾病

合作單位：廣州醫(yī)科大學(xué)、廣東省兒童醫(yī)院、北京中醫(yī)藥大學(xué)

研究?jī)?nèi)容：大規(guī)模調(diào)查孕婦和兒童的腸道、口腔和生殖道微生物組特征，開發(fā)針對(duì)性的益生菌和微生物制劑，為改善女性和兒童的健康保駕護(hù)航。

研究成果：

1. ..., Wen Sun. (2022) Metagenomic-based characterization of the gut virome in patients with polycystic ovary syndrome. Frontiers in Cellular and Infection Microbiology.
2. ..., Shenghui Li, ... (2022) Deep metagenomic characterization of gut microbial community and function in preeclampsia. Frontiers in Cellular and Infection Microbiology.
3. ..., Shenghui Li, ... (2021) Is oral microbiome of children able to maintain resistance and functional stability in response to short-term interference of ingesta. Protein & Cell.
4. ..., Ruochun Guo, ... (2021) Gut microbiota signatures in gestational anemia. Frontiers in Cellular and Infection Microbiology.
5. ..., Ruochun Guo, ... (2020) Systematic analysis of gut microbiota in pregnant women and its correlations with individual heterogeneity. npj Biofilms and Microbiomes.
6. ..., Shenghui Li, ... (2019) Early-onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women. Frontiers in Cellular and Infection Microbiology.
7. ..., Shenghui Li, ... (2017) Connections between human gut microbiome and gestational diabetes mellitus. GigaScience.
8. ..., Shenghui Li, ... (2016) Effect of short-term room temperature storage on the microbial community in infant fecal samples. Scientific Reports.
9. ..., Shenghui Li, ... (2016) Composition of gut microbiota in infants in China and global comparison. Scientific Reports.

動(dòng)物和環(huán)境微生物

合作單位：華南農(nóng)業(yè)大學(xué)、青島農(nóng)業(yè)大學(xué)

研究?jī)?nèi)容：研究動(dòng)物和環(huán)境的微生物組和耐藥組特征，探索人類微生物與動(dòng)物和環(huán)境的關(guān)系，為預(yù)防感染、減少抗生素使用提供新的思路；對(duì)動(dòng)物疾病的檢測(cè)和干預(yù)也提供幫助。

研究成果：

1. ..., Shenghui Li, ... (2022) A catalog of over 5,000 metagenome-assembled microbial genomes from the Caprinae gut microbiota. Microbiology Spectrum.
2. ..., Shenghui Li, ... (2020) Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms. Nature Communications.
3. ..., Shenghui Li, ... (2019) Characterization of the pig gut microbiome and antibiotic resistome in industrialized feedlots in China. mSystems.
4. ..., Qiulong Yan, ... (2018) Isolation of γ-glutamyl-transferase rich-bacteria from mouse gut by a near-infrared fluorescent probe with large stokes shift. Analytical Chemistry.
5. ..., Qiulong Yan, ... (2018) Diterpenoids from the roots of Euphorbia ebracteolata and their anti-tuberculosis effects. Bioorganic Chemistry.

微生物組新技術(shù)與新方法

合作單位：華中科技大學(xué)、南京中醫(yī)藥大學(xué)、內(nèi)蒙古農(nóng)業(yè)大學(xué)

研究?jī)?nèi)容：探索微生物基因組學(xué)和宏基因組學(xué)領(lǐng)域新技術(shù)與新方法，目前的工作包括mNGS病原體檢測(cè)技術(shù)、宏病毒組學(xué)技術(shù)、高深度測(cè)序、細(xì)菌群體遺傳學(xué)研究等。

研究成果：

1. ..., Shenghui Li, ... (2022) Hybrid, ultra-deep metagenomic sequencing enables genomic and functional characterization of low-abundance species in the human gut microbiome. Gut Microbes.
2. Guangyang Wang, ... (2022) Optimization and evaluation of viral metagenomic amplification and sequencing procedures toward a genome-level resolution of the human fecal DNA virome. Journal of Advanced Research.
3. Shenghui Li, ... (2022) A catalogue of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome. iScience.
4. ..., Shenghui Li, ... (2022) A thousand metagenome-assembled genomes of Akkermansia reveal phylogroups and geographical and functional variations in the human gut. Frontiers in Cellular and Infection Microbiology.
5. Qiulong Yan, ... (2021) Characterization of the gut DNA and RNA viromes in a cohort of Chinese residents and visiting Pakistanis. Virus Evolution.
6. ..., Shenghui Li, ... (2017) Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diverisity, and global distribution in mammalian gut microbiotas. BMC Genomics.
7. Qiulong Yan, ... (2016) Metagenomic analysis of sputum microbiome as a tool toward culture-independent pathogen detection of patients with ventilator-associated pneumonia. American Journal of Respiratory and Critical Care Medicine.